Pathogenesis of Meningoencephalitis in Rabbits by Bovine Herpesvirus Type-5 (bhv-5)
نویسندگان
چکیده
Departamento de Medicina Veterinária Preventiva-DMVP, Microbiologia e Parasitologia/DMP, Departamento de Patologia da Universidade Federal de Santa Maria-UFSM. Santa Maria, RS, Brasil. Centro de Pesquisas Veterinárias Desidério Finamor (CPVDF), Eldorado do Sul, RS, Brasil and Departamento de Microbiologia. Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil. Universidade do Estado de Santa Catarina, Centro de Pesquisas Agroveterinárias, Lages, SC, Brasil.
منابع مشابه
Neurovirulence of glycoprotein C(gC)-deleted bovine herpesvirus type-5 (BHV-5) and BHV-5 expressing BHV-1 gC in a rabbit seizure model.
Herpesvirus glycoprotein C (gC) is one of the major virus attachment proteins. Bovine herpesvirus type 1 (BHV-1) causes respiratory and genital diseases in cattle, whereas BHV-5 causes acute meningoencephalitis in calves. The gC gene sequence of these two viruses are substantially different. To determine the contribution of the BHV-5 glycoprotein gC (gC5) to the neuropathogenesis of BHV-5, we h...
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Bovine herpesvirus type 5 (BHV-5) is a major agent of meningoencephalitis in cattle and establishes latent infections mainly in sensory nerve ganglia. The distribution of latent BHV-5 DNA in the brain of rabbits prior to and after virus reactivation was studied using a nested PCR. Fifteen rabbits inoculated intranasally with BHV-5 were euthanized 60 days post-inoculation (group A, N = 8) or sub...
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Here we present the complete genomic sequence of bovine herpesvirus 5 (BHV-5), an alphaherpesvirus responsible for fatal meningoencephalitis in cattle. The 138390-bp genome encodes 70 putative proteins and resembles the alpha2 subgroup of herpesviruses in genomic organization and gene content. BHV-5 is very similar to BHV-1, the etiological agent of infectious bovine rhinotracheitis, as reflect...
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